Selective loss of levator ani and leg muscle volumes in men undergoing androgen deprivation therapy

AS Cheung; C Cunningham; DK Ko; V Ly; H Gray; R Hoermann; BJG Strauss; EB Hassan; G Duque; P Ebeling; MG Pandy; JD Zajac; M Grossmann

Journal article

Selective loss of levator ani and leg muscle volumes in men undergoing androgen deprivation therapy

AS Cheung, C Cunningham, DK Ko, V Ly, H Gray, R Hoermann, BJG Strauss, EB Hassan, G Duque, P Ebeling, MG Pandy, JD Zajac, M Grossmann

Journal of Clinical Endocrinology and Metabolism | ENDOCRINE SOC | Published : 2019

DOI: 10.1210/jc.2018-01954

Abstract

Objective: To determine whether the high androgen responsiveness of the levator ani muscle documented in rodents is evolutionarily conserved and ADT is associated with a selective loss in leg muscle volume. Design: Prospective longitudinal case-control study. Setting: Tertiary referral hospital. Participants: Thirty-four men newly beginning ADT and 29 age-matched controls with PCa. Main Outcome Measures: The muscle volumes in liters of the levator ani and primary muscles involved in walking (iliopsoas, quadriceps, gluteus maximus, gluteus medius, calf). Results: Compared with controls, during a 12-month period, men receiving ADT experienced a mean reduction in total testosterone from 14.1 to..

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University of Melbourne Researchers

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Grants

Awarded by Sylvia and Charles Viertel Charitable Foundation

Funding Acknowledgements

The present study was supported by the National Health and Medical Research Council of Australia (NHMRC)(project grant 1006407). A.S.C. was supported by an NHMRC scholarship (grant 1017233), NHMRC early career fellowship (grant 1143333), and a Viertel Charitable Foundation Clinical Investigator Award. M.G. was supported by a NHMRC Career Development Fellowship (grant 1024139).